Radiopharm Theranostics (ASX:RAD, ‘Radiopharm’ or the ‘Company’), a clinical-stage biopharmaceutical company focused on developing innovative oncology radiopharmaceuticals for areas of high unmet medical need, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation for RAD101 to distinguish between recurrent disease and treatment effect of brain metastases originating from solid tumors of different origin including leptomeningeal disease.

RAD101 is the Company’s novel imaging small molecule that targets fatty acid synthase (FASN), a multi-enzyme protein that catalyses fatty acid synthesis and is overexpressed in many solid tumors, including cerebral metastases.

‘The FDA’s Fast Track Designation for RAD101 highlights the seriousness of recurrent brain metastases as a condition and the unmet medical need for innovative products that can differentiate between tumor recurrence and radiation necrosis or pseudprogression,’ said Riccardo Canevari, CEO and Managing Director of Radiopharm Theranostics. ‘RAD101 represents a promising advancement in improving diagnostic precision for brain metastases, offering hope for more effective clinical decision-making in the over 300,000 patients diagnosed annually in the U.S. We are excited to advance our Phase 2 clinical trial and anticipate sharing topline results in the second half of 2025.’

The FDA’s Fast Track designation is designed to facilitate the development and expedite the review of drugs that are intended to treat serious or life-threatening conditions and demonstrate the potential to address an unmet medical need. A Sponsor that receives Fast Track designation may be eligible for more frequent meetings and communications with the FDA and rolling review of any application for marketing approval. A Sponsor’s drug receiving Fast Track designation also may be eligible for Priority Review if relevant criteria are met.

About the Phase 2 Clinical Trial of RAD101

The U.S. multicenter, open-label, single arm Phase 2b clinical trial is evaluating the diagnostic performance of 18F-RAD101 in 30 individuals with confirmed recurrent brain metastases from solid tumors of different origins. The primary objective of the study is concordance between 18F-RAD101 positive lesions and those seen in conventional imaging (MRI with gadolinium) in participants with suspected recurrent brain metastases. Secondary endpoints are accuracy, sensitivity and specificity of RAD101 in identifying tumor recurrence versus radiation necrosis in previously stereotactic radiosurgery (SRS)-treated brain metastases.

About RAD101

RAD101 is the Company’s novel imaging small molecule that targets fatty acid synthase (FASN), a multi-enzyme protein that catalyses fatty acid synthesis and is overexpressed in many solid tumors, including cerebral metastasis. Targeting FASN activity may allow for the more accurate detection of cancer cells, representing a clinically relevant method for the imaging of brain metastases. Positive data from the Imperial College of London’s Phase 2a imaging trial of 18F-RAD101 in patients with brain metastases (both SRS pre-treated and treatment naïve patients) showed significant tumor uptake that was independent from the tumor of origin. The study further indicated that PET-MRI may potentially represent a non-invasive prediction of overall-survival, warranting larger studies.

About Radiopharm Theranostics

Radiopharm Theranostics is a clinical stage radiotherapeutics company developing a world-class platform of innovative radiopharmaceutical products for diagnostic and therapeutic applications in areas of high unmet medical need. Radiopharm is listed on ASX (RAD) and on NASDAQ (RADX). The company has a pipeline of distinct and highly differentiated platform technologies spanning peptides, small molecules and monoclonal antibodies for use in cancer. The clinical program includes one Phase 2 and three Phase 1 trials in a variety of solid tumor cancers including lung, breast, and brain metastases. Learn more at radiopharmtheranostics.com .

Authorised on behalf of the Radiopharm Theranostics board of directors by Chairman Paul Hopper.

For more information:

Riccardo Canevari
CEO & Managing Director
P: +1 862 309 0293
E: rc@radiopharmtheranostics.com

Anne Marie Fields
Precision AQ (Formerly Stern IR)
E: annemarie.fields@precisionaq.com

Paul Hopper
Executive Chairman
P: +61 406 671 515
E: paulhopper@lifescienceportfolio.com

Media
Matt Wright
NWR Communications
P: +61 451 896 420
E: matt@nwrcommunications.com.au

(TheNewswire)

As global demand for rare earth magnets accelerates—driven by electric vehicles, renewable energy systems, and high-performance computing—the need for secure, domestic sources of these critical materials has become a strategic priority for the United States. The article explores how rare earth recycling is emerging as a viable and scalable response to supply chain risks and environmental concerns.

Featured in the article is CoTec Holdings Corp. (TSXV: CTH | OTCQB: CTHCF) , a Vancouver-based company advancing a low-emission, high-efficiency rare earth magnet recycling technology through its U.S. joint venture with HyProMag USA. The company’s process—developed by researchers at the University of Birmingham—uses hydrogen to extract high-purity magnet powder from end-of-life products, eliminating the need for high-temperature smelting or chemical leaching.

CoTec, which owns a majority interest in HyProMag USA, is developing a rare earth magnet recycling facility in the Dallas–Fort Worth region, positioning it to serve U.S. manufacturing and defense industries with domestically sourced materials.

About CoTec

CoTec is a publicly traded investment issuer listed on the TSXV and the OTCQB and trades under the symbols CTH and CTHCF respectively. CoTec is a forward-thinking resource extraction company committed to revolutionizing the global metals and minerals industry through innovative, environmentally sustainable technologies and strategic asset acquisitions. With a mission to drive the sector toward a low-carbon future, CoTec employs a dual approach: investing in disruptive mineral extraction technologies that enhance efficiency and sustainability while applying these technologies to undervalued mining assets to unlock their full potential. By focusing on recycling, waste mining, and scalable solutions, the Company accelerates the production of critical minerals, shortens development timelines, and reduces environmental impact. CoTec’s strategic model delivers low capital requirements, rapid revenue generation, and high barriers to entry, positioning it as a leading mid-tier disruptor in the commodities sector.

For more information, please visit www.cotec.ca.

Copyright (c) 2025 TheNewswire – All rights reserved.

(TheNewswire)

TORONTO TheNewswire – June 11, 2025 Noble Mineral Exploration Inc. (‘ Noble ‘ or the ‘ Company ‘) (TSXV: NOB) (OTCQB: NLPXF) is pleased to announce the initial mineral resource at Mann West as announced by its joint venture partner Canada Nickel in the East Timmins Nickel Company, operating in the Timmins area of Northern Ontario.

Noble CEO Vance White said ‘We congratulate our partner Canada Nickel on the work completed and the Initial Resource estimate for Mann West project in Mann Twp and we are very excited about the prospects for East Timmins Nickel along with the several additional projects to be included.’

Highlights:

• Mann West is the third of eight new nickel resources expected to be published in 2025

TORONTO, June 11, 2025 – Canada Nickel Company Inc. (‘ Canada Nickel ‘ or the ‘ Company ‘) (TSX-V:CNC) (OTCQB: CNIKF) today announced an initial mineral resource estimate (the ‘Mineral Resource Estimate’ or ‘MRE’) for its Mann West Nickel Sulphide Project (‘Mann West’) near Timmins, Ontario. Mann West is wholly owned by East Timmins Nickel Ltd. of which Canada Nickel owns 80% and Noble Mineral Exploration Inc. owns 20%.

The Mann West Nickel Sulphide Project is located just 21 kilometres east of the Company’s Crawford Nickel Sulphide Project (‘Crawford’) and is more than twice the size of Crawford based on the outline of its geophysical target of 3.4 square kilometres. The area of the geophysical target covered by the Mann West resource represents approximately 40% of the total target area. The Mann West project is accessible year-round.

Mark Selby, CEO of Canada Nickel said, ‘Mann West marks a significant milestone with today’s announcement, demonstrating a resource that surpasses the size and scale of our initial Crawford resource, and that validates our belief in the potential of the Timmins Nickel District. With a target footprint more than double Crawford’s, Mann West is just the third of eight new mineral resources we expect to announce by the end of 2025, including two more this month.’

Mann West Mineral Resource Estimate

For the initial Mineral Resource Estimate, a total of 16,833 metres of core drilling in 37 drill holes were utilized to calculate the Mann West Resources in two categories as provided in Table 1. Indicated Resources totalled 406 million tonnes grading 0.23% nickel, for a total of 0.95 million tonnes of contained nickel and Inferred Resources totalled 599 million tonnes grading 0.22% nickel, for a total of 1.31 million tonnes of contained nickel. The approximate dimensions of the resource are 1.9 kilometres long, 800 metres wide, extending to 500 metres deep and remaining open to the northwest and at depth. An additional 0.5 – 1.0 billion tonnes grading between 0.20% and 0.22% nickel remain as an Exploration Target, pending further drilling. This Exploration Target is based on core drilling by the Company, the geophysical survey on the Project, and the understanding and calculation of the current MRE. Within the resource, a PGM Zone containing an Indicated resource of 7.0 million tonnes grading 0.422 g/t palladium + platinum and an Inferred resource of 7.7 million tonnes grading 0.411 g/t palladium + platinum.

The Exploration Target was derived by modelling the identified nickel sulphide mineralization within the current estimation envelope but outside of the current Mineral Resource Estimate area.

The volume of the modelled Exploration Target area determines the potential tonnage statement in the Exploration Target. The grade range given in the Exploration Target is determined with consideration to the drill core results within the modelled Exploration Target area, consideration of the geological setting in a well understood nickel deposit type where grades are observed and well understood, and based on the experience of the Company and the Qualified Persons. The potential tonnages and grades are conceptual in nature and are based on drill holes and geophysical results that define the approximate length, thickness, depth and grade of the Exploration Target. There has been insufficient exploration to define a current mineral resource and the Company cautions that there is a risk that further exploration will not result in the delineation of a current mineral resource.

Drilling at Mann West was completed in 2023 and 2024. The 2024 campaign successfully completed the goal of infilling previous sections to allow for the definition of an initial mineral resource estimate, gain understanding on the geology of the deposit, as well as systematically collecting samples for mineralogical analysis that have started to help define the potential of nickel recovery (see May 13, 2024 news release).

The Mann West Mineral Resource Estimate was prepared by Caracle Creek International Consulting Inc. in accordance with CIM Estimation of Mineral Resources & Mineral Reserves Best Practice Guidelines (2019) and CIM Definition Standards for Mineral Resources & Mineral Reserves (2014). A Technical Report in support of the Mineral Resource Estimate will be filed on SEDAR+ ( www.sedarplus.ca ) within 45 days of this news release.

Table 1. Initial Total Mineral Resource Estimate (in-pit resources) for the Mann West Nickel Sulphide Deposit.

Table 2. Initial PGE Zone Mineral Resource Estimate (in-pit resources) for the Mann West Nickel Sulphide Deposit.

*Totals may not add due to rounding.

Notes to Table 1 and Table 2:

1. The independent Qualified Person for the Mineral Resource Estimate (‘MRE’), as defined by National Instrument 43-101 (‘NI 43-101’), is Dr. Scott Jobin-Bevans (P.Geo., PGO #0183), of Caracle Creek International Consulting Inc. The effective date of the Mineral Resource Estimate is May 30, 2025.

2. The quantity and grade of reported Inferred Resources in this MRE are uncertain in nature and there has been insufficient exploration to define these Inferred Resources as Indicated or Measured. However, it is reasonably expected that the majority of Inferred Mineral Resources could be upgraded to Indicated Mineral Resources with continued exploration.

3. A cut-off grade of 0.10% Ni was used to define potentially economic material for inclusion within the MRE. Cut-offs were determined on the based on core assay geostatistics and drill core lithologies for the deposit, and by comparison to analogous nickel deposit types.

4. Geological and block models for the MRE used data from a total of 37 surface drill holes, completed by Canada Nickel in 2023 and 2024. The drill hole database was validated prior to resource estimation and QA/QC checks were made using industry-standard control charts for blanks, core duplicates and commercial certified reference material inserted into assay batches by Canada Nickel and by comparison of umpire assays performed at a second laboratory.

5. Estimates have been rounded to two significant figures.

6. The MRE was prepared following the CIM Estimation of Mineral Resources Mineral Reserves Best Practice Guidelines (November 29, 2019) and the CIM Definition Standards for Mineral Resources Mineral Reserves (May 19, 2014).

7. The geological model as applied to the MRE comprises three mineralized domains hosted by variably serpentinized ultramafic rocks: a relatively higher-grade core (dunite), a lower grade (peridotite), and a PGE-rich pyroxenite ‘reef’. Individual wireframes were created for each domain in Leapfrog Geo 2024.1 software.

8. A 20 m x 20 m x 15 m block model was created, and samples were composited at 7.5 m intervals. Grade estimation from drill hole data was carried out for Ni, Co, Fe, Cr, S, Pd and Pt using the Ordinary Kriging interpolation method in Isatis 2024.04 software.

9. The MRE has been constrained by a conceptual pit envelope that was developed using the following optimization parameters. Metal prices used were US$21,000/t nickel, US$40,000/t cobalt, US$325/t iron, US$3,860/t chromium, US$1,350/oz palladium, and US$1,150/oz platinum. Different pit slopes were used for each layer (in degrees): 9.5 in overburden, and 40.0 in mineralized rock, and 45 in waste rock. Exchange rate utilized was US$/C$ at $0.76. Mining costs utilized different values for overburden (clay, gravel), and rock mining, ranging from C$1.47 to C$3.53/t mined. Processing costs and general and administration costs for a 120 ktpd operation (similar to the ultimate scope of Crawford) were C$8.30/t. Based on the range of grade and ratio of sulphur to nickel, calculated recovery averages 45% for Ni, 7% for Co, 56% for Fe, 29% for Cr 45% for Pd and 28% for Pd.

10. Grade estimation was validated by comparison of input and output statistics (Nearest Neighbour and Inverse Distance Squared methods), swath plot analysis, cross-plots of declustered samples against the nearest OK estimate, and by visual inspection of the assay data, block model, and grade shells in cross-sections.

11. Density estimation was carried out for the mineralized domains using the Ordinary Kriging interpolation method, based on 1,740 specific gravity measurements collected during the core logging process, using the same block model parameters of the grade estimation. As a reference, the average estimated density value within dunite is 2.64 g/cm (t/m ), while the peridotite domain yielded an average of 2.74 g/cm (t/m ), and the PGE ‘reef’ domain an average of 3.05 g/cm (t/m ).

Figure 1. Plan View of Mann West Nickel Sulphide Resources, Mann West Nickel Sulphide Project, Ontario.

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Figure 2. Plan View of the Mann West Resource Categories and Nickel Grade.

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Figure 3. Mann West Nickel Sulphide Project Long-Section (Looking North) of Resource Categories (TOP) and Nickel Grade (BOTTOM).

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Next Steps at Mann West:

• A technical report with respect to the Mineral Resource Estimate disclosed today will be filed within 45 days.

• Infill drilling at the property will aim to increase and upgrade inferred resources in the next drilling campaign.

• Mineralogical and metallurgical analysis will continue to better understand and estimate metal recoveries.

Assays, Quality Assurance/Quality Control and Drilling

Edwin Escarraga, MSc, P.Geo., a ‘Qualified Person’ within the meaning of NI 43-101, is responsible for the on-going drilling and sampling program, including quality assurance (QA) and quality control (QC). The core is collected from the drill in sealed core trays and transported to the secure core logging facility (core shack). The core is marked and sampled at 1.5 metre lengths and cut with a diamond blade saw. One set of samples is transported in secured bags directly from the Canada Nickel core shack to Actlabs Timmins, while a second set of samples is securely shipped to SGS Lakefield for preparation, with analysis performed at SGS Burnaby. All are ISO/IEC 17025 accredited labs and independent of Canada Nickel. Analysis for precious metals (gold, platinum, and palladium) are completed by Fire Assay while analysis for nickel, cobalt, sulphur and other elements are performed using a peroxide fusion and ICP-OES analysis. Certified standards and blanks (QA/QC samples) are inserted at a rate of three QA/QC samples per 20 core samples making a batch of 60 samples that are submitted for analysis.

Qualified Person and Data Verification

Stephen J. Balch (P.Geo. – Ontario), VP Exploration of Canada Nickel and a ‘Qualified Person’ within the meaning of NI 43-101, has verified the data disclosed in this news release, and has otherwise reviewed and approved the technical information in this news release on behalf of Canada Nickel Company Inc.

The magnetic images shown in this news release were created from Canada Nickel’s interpretation of datasets provided by the Ontario Geological Survey.

About Canada Nickel Company

Canada Nickel Company Inc. is advancing the next generation of nickel-sulphide projects to deliver nickel required to feed the high growth electric vehicle and stainless-steel markets. Canada Nickel Company has applied in multiple jurisdictions to trademark the terms NetZero Nickel TM , NetZero Cobalt TM , NetZero Iron TM and is pursuing the development of processes to allow the production of net zero carbon nickel, cobalt, and iron products. Canada Nickel provides investors with leverage to nickel in low political risk jurisdictions. Canada Nickel is currently anchored by its 100% owned flagship Crawford Nickel-Cobalt Sulphide Project in the heart of the prolific Timmins-Nickel District. For more information, please visit www.canadanickel.com.

About Noble Mineral Exploration Inc.

Noble Mineral Exploration Inc. is a Canadian-based junior exploration company, which has holdings of securities in Canada Nickel Company Inc., Homeland Nickel Inc., East Timmins Nickel Inc.(20%), and its interest in the Holdsworth gold exploration property in the area of Wawa, Ontario.

Noble holds mineral and/or exploration rights in ~70,000ha in Northern Ontario, ~14,000ha elsewhere in Quebec and Newfoundland, upon which it plans to generate option/joint venture exploration programs .

Noble holds mineral rights and/or exploration rights in ~18,000 hectares in the Timmins-Cochrane areas of Northern Ontario known as Project 81, ~2,215 hectares in Thomas Twp/Timmins, as well as an additional 20% interest in ~38,700 hectares in the Timmins area and ~175 hectares of mining claims in Central Newfoundland. Project 81 hosts diversified drill-ready gold, nickel-cobalt and base metal exploration targets at various stages of exploration. Noble also holds ~4,600 hectares in the Nagagami Carbonatite Complex and its ~3,200 hectares in the Boulder Project both near Hearst, Ontario, as well as ~3,700 hectares in the Buckingham Graphite Property, ~10,152 hectares in the Havre St Pierre  Nickel, Copper, PGM property, and ~1,573 hectares in the Cere-Villebon Nickel, Copper, PGM property, ~569 hectare Uranium/Rare Earth property (Chateau) and a ~461 hectare Uranium/Molybdenum property (Taser North),  all of which are in the province of Quebec.

Noble’s common shares trade on the TSX Venture Exchange under the symbol ‘NOB.’

More detailed information on Noble is available on the website at www.noblemineralexploration.com .

Cautionary Note and Statement Concerning Forward Looking Statements

This press release contains certain information that may constitute ‘forward-looking information’ under applicable Canadian securities legislation.  Forward looking information includes, but is not limited to, the potential of the Mann West Nickel Sulphide Project, timing for filing a technical report in support of the Mineral Resource Estimate, the significance of drill results, the ability to continue drilling, the impact of drilling on the definition of any resource, timing and completion (if at all) of additional mineral resource estimates, the potential of the Timmins Nickel District, strategic plans, including future exploration and development plans and results, and corporate and technical objectives.  Forward-looking information is necessarily based upon several assumptions that, while considered reasonable, are subject to known and unknown risks, uncertainties, and other factors which may cause the actual results and future events to differ materially from those expressed or implied by such forward-looking information.  Factors that could affect the outcome include, among  others:  future prices and the supply of metals, the future demand for metals, the results of drilling, inability to raise  the money necessary to incur the expenditures required to retain and advance the property, environmental liabilities  (known  and  unknown), general business, economic, competitive, political and social uncertainties, results of  exploration programs, risks of the mining industry, delays in obtaining governmental approvals, failure to obtain  regulatory or shareholder approvals.  There can be no assurance that such information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such information.  Accordingly, readers should not place undue reliance on forward-looking information.  All forward-looking information contained in this press release is given as of the date hereof and is based upon the opinions and estimates of management and information available to management as at the date hereof.  Canada Nickel disclaims any intention or obligation to update or revise any forward-looking information, whether because of new information. Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Contacts:

H. Vance White, President

Phone:        416-214-2250

Fax:        416-367-1954

Email: info@noblemineralexploration.com

Investor Relations

Email: ir@noblemineralexploration.com   

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